Function of GAS6/TAM (AXL) pathway
The GAS6-AXL signaling pathway is key to tumor cell growth, cancer metastasis, immune escape and drug tolerance. AXL is reported to be up-regulated in multiple cancer types including acute myeloid leukemia (AML), kidney cancer, pancreatic cancer, breast cancer, lung cancer, ovarian cancer and prostate cancer. Increased expression of AXL and GAS6 in tumors has been correlated with poor prognosis and decreased survival and has been implicated in therapeutic resistance to conventional chemotherapeutics and targeted therapies. Preclinical studies have proved the anti-tumor activity of GAS6-AXL inhibition, either alone or its combination with a variety of antie-cancer therapies, including radiation therapy, immuno-oncology agents, and chemotherapeutic drugs. As a result, GAS6-AXL has attracted wide attention as a new target for cancer treatment.